[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

M Farahani, Z Niknam, LM Amirabad… - Biomedicine & …, 2022 - Elsevier
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …

Host factors in coronavirus replication

AH De Wilde, EJ Snijder, M Kikkert… - Roles of host gene and …, 2018 - Springer
Coronaviruses are pathogens with a serious impact on human and animal health. They
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …

[HTML][HTML] SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses

AK Banerjee, MR Blanco, EA Bruce, DD Honson… - Cell, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …

A scoping review of the pathophysiology of COVID-19

PE Marik, J Iglesias, J Varon… - International journal of …, 2021 - journals.sagepub.com
COVID-19 is a highly heterogeneous and complex medical disorder; indeed, severe COVID-
19 is probably amongst the most complex of medical conditions known to medical science …

Improving mRNA-based therapeutic gene delivery by expression-augmenting 3′ UTRs identified by cellular library screening

AGO von Niessen, MA Poleganov, C Rechner… - Molecular Therapy, 2019 - cell.com
Synthetic mRNA has emerged as a powerful tool for the transfer of genetic information, and it
is being explored for a variety of therapeutic applications. Many of these applications require …

Immune responses and immunoprotection in crustaceans with special reference to shrimp

A Kulkarni, S Krishnan, D Anand… - Reviews in …, 2021 - Wiley Online Library
Crustacean aquaculture, dominated by shrimp, is a highly profitable food‐producing sector
in the world. However, a variety of biotic and abiotic stressors can have adverse effect on the …

A diverse range of gene products are effectors of the type I interferon antiviral response

JW Schoggins, SJ Wilson, M Panis, MY Murphy… - Nature, 2011 - nature.com
The type I interferon response protects cells against invading viral pathogens. The cellular
factors that mediate this defence are the products of interferon-stimulated genes (ISGs) …

Pathogen recognition by the innate immune system

H Kumar, T Kawai, S Akira - International reviews of immunology, 2011 - Taylor & Francis
Microbial infection initiates complex interactions between the pathogen and the host.
Pathogens express several signature molecules, known as pathogen-associated molecular …

Pattern recognition receptors and central nervous system repair

KA Kigerl, JP de Rivero Vaccari, WD Dietrich… - Experimental …, 2014 - Elsevier
Pattern recognition receptors (PRRs) are part of the innate immune response and were
originally discovered for their role in recognizing pathogens by ligating specific pathogen …

Developing mRNA-vaccine technologies

T Schlake, A Thess, M Fotin-Mleczek, KJ Kallen - RNA biology, 2012 - Taylor & Francis
mRNA vaccines combine desirable immunological properties with an outstanding safety
profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression …