The cognitive effect of anticholinergics for patients with overactive bladder

B Welk, K Richardson, JN Panicker - Nature Reviews Urology, 2021 - nature.com
Overactive bladder (OAB) is often treated with medications that block the cholinergic
receptors in the bladder (known as anticholinergics). The effect of this medication class on …

Current and emerging pharmacological targets and treatments of urinary incontinence and related disorders

MC Michel, L Cardozo, CJ Chermansky, F Cruz… - Pharmacological …, 2023 - ASPET
Overactive bladder syndrome with and without urinary incontinence and related conditions,
signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract …

Cognitive effects of anticholinergic load in women with overactive bladder

G Araklitis, D Robinson, L Cardozo - Clinical Interventions in Aging, 2020 - Taylor & Francis
Overactive bladder syndrome (OAB) is defined as urinary urgency, usually accompanied by
frequency and nocturia, with or without urgency incontinence, in the absence of urinary tract …

Patient and clinician challenges with anticholinergic step therapy in the treatment of overactive bladder: a narrative review

RR Dmochowski, DK Newman, ES Rovner… - Advances in …, 2023 - Springer
Anticholinergics have been used in the treatment of overactive bladder (OAB), but their use
is limited by poor tolerability and anticholinergic-related side effects. Increasingly, providers …

Updating the evidence on drugs to treat overactive bladder: a systematic review

FC Hsu, CE Weeks, SS Selph, I Blazina… - International …, 2019 - Springer
Introduction Overactive bladder (OAB) is a common condition, increasing with age and
affecting quality of life. While numerous OAB drugs are available, persistence is low. We …

Ageing influences detrusor contractions to prostaglandin, angiotensin, histamine and 5-HT (serotonin), independent to the Rho kinase and extracellular calcium …

C Phelps, R Chess-Williams, C Moro - Scientific Reports, 2023 - nature.com
Ageing is associated with deteriorating urinary bladder function and an increasing
prevalence of disorders such as underactive bladder. There are suggestions that G protein …

The risk of delirium and falls or fractures with the use of overactive bladder anticholinergic medications

B Welk, K Etaby, E McArthur… - Neurourology and …, 2022 - Wiley Online Library
Objective To determine if OAB anticholinergics have an increased risk of delirium or
falls/fractures relative to OAB beta‐3 agonist medications. Methods This was a retrospective …

Persistence with mirabegron or antimuscarinic treatment for overactive bladder syndrome: findings from the PERSPECTIVE registry study

KV Carlson, ES Rovner, KV Nair… - LUTS: Lower Urinary …, 2021 - Wiley Online Library
Objectives This analysis from the PERSPECTIVE (a Prospective, Non‐interventional
Registry Study of Patients Initiating a Course of Drug Therapy for Overactive Bladder) study …

The dependence of urinary bladder responses on extracellular calcium varies between muscarinic, histamine, 5-HT (serotonin), neurokinin, prostaglandin, and …

C Phelps, R Chess-Williams, C Moro - Frontiers in Physiology, 2022 - frontiersin.org
With many common bladder diseases arising due to abnormal contractions, a greater
understanding of the receptor systems involved may aid the development of future …

Evaluating the safety and potential activity of URO‐902 (hMaxi‐K) gene transfer by intravesical instillation or direct injection into the bladder wall in female participants …

E Rovner, TC Chai, S Jacobs, G Christ… - Neurourology and …, 2020 - Wiley Online Library
Aims Two phase 1 trials were performed in healthy women with the overactive bladder
(OAB) syndrome and urodynamically demonstrated detrusor overactivity (DO), with the aim …