Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Neuroactive steroids are endogenous neuromodulators synthesised in the brain that rapidly
alter neuronal excitability by binding to membrane receptors, in addition to the regulation of …

Rationale Preclinical studies indicate that gonadal hormones are important determinants of
drug self-administration. To date, little is known about the influence of sex and estrous cycle …

The importance of studying sex as a biological variable in biomedical research is becoming
increasingly apparent. There is a particular need in preclinical studies of addiction to include …

Chronic cocaine use leads to adaptations in stress biology and in neuroactive steroid
system. These adaptations are associated with high cocaine craving and increased relapse …

The application of behavioral economic demand theory in addiction science has proved
useful for evaluating individual characteristics underlying abuse liability. Two factors that …

The neurosteroid 3α, 5α-THP is a potent GABAA receptor-positive modulator and its
regulatory action on the HPA axis stress response has been reported in numerous …

The main fast-acting inhibitory receptors in the mammalian brain are γ-aminobutyric acid
type-A (GABA A) receptors for which neurosteroids, a subclass of steroids synthesized de …

It has recently been proposed that the intermittent access (IntA) drug self-administration
procedure better produces behavioral changes relevant to addiction than the long access …

BACKGROUND: Methamphetamine (METH) use has increased substantially in the last 10
years and poses a serious health concern, especially for young populations. Drug abuse …