Human brain imaging has identified structural changes in gray and white matter that occur
with learning. However, ascribing imaging measures to underlying cellular and molecular …

The study of neuroanatomy using imaging enables key insights into how our brains function,
are shaped by genes and environment, and change with development, aging and disease …

Several MRI measures have been proposed as in vivo biomarkers of myelin, each with
applications ranging from plasticity to pathology. Despite the availability of these myelin …

During the last five years ultra-high-field magnetic resonance imaging (MRI) has enabled an
unprecedented view of living human brain. Brain tissue contrast in most MRI sequences is …

The current knowledge of the normal biochemistry of compounds that give rise to
resonances in human brain proton magnetic resonance spectra measureable at readily …

Myelin is critical for healthy brain function. An accurate in vivo measure of myelin content
has important implications for understanding brain plasticity and neurodegenerative …

The role of immune activation in psychiatric disorders has attracted considerable attention
over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the …

Multiexponential T2 relaxation time measurement in the central nervous system shows a
component that originates from water trapped between the lipid bilayers of myelin. This …

Here, we describe a quantitative neuroimaging method to estimate the macromolecular
tissue volume (MTV), a fundamental measure of brain anatomy. By making measurements …

Purpose Within multiple sclerosis (MS) lesions iron is present in chronically activated
microglia. Thus, iron detection with MRI might provide a biomarker for chronic inflammation …