Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Several lines of preclinical and clinical research have confirmed that chronic low-grade
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …

Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

To date, single-cell studies of human white adipose tissue (WAT) have been based on small
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …

Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …

The complex relationship between metabolic disease risk and body fat distribution in
humans involves cellular characteristics that are specific to body fat compartments. Here we …

The high prevalence of obesity is associated with an enormous medical, social, and
economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by …

Obesity, the major cause of the current global epidemic of type 2 diabetes (T2D), induces
insulin resistance in peripheral insulin target tissues. Several mechanisms have been …

Chronic inflammation in adipose tissue, possibly related to adipose cell hypertrophy,
hypoxia, and/or intestinal leakage of bacteria and their metabolic products, likely plays a …

The prevalence of obesity has recently increased dramatically and has contributed to the
increasing prevalence of various pathological conditions, including type 2 diabetes mellitus …