Articular cartilage injuries and degenerative joint diseases are responsible for progressive
pain and disability in millions of people worldwide, yet there is currently no treatment …

As the cellular component of articular cartilage, chondrocytes are responsible for
maintaining in a low-turnover state the unique composition and organization of the matrix …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the
regulation of expression of numerous genes in the setting of the inflammatory response …

Chondrocytes are the single cellular component of hyaline cartilage. Under physiologic
conditions, they show steady-state equilibrium between anabolic and catabolic activities that …

This review examines a mechanism for the initiation of osteoarthritis after anterior cruciate
ligament (ACL) injury by considering the relationship between reported ambulatory changes …

Painful intervertebral disc disease is characterised not only by an imbalance between
anabolic (ie, matrix synthesis) and catabolic (ie, matrix degradation) processes, but also by …

In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in
response to alterations in the environment owing to mechanical injury and inflammation …

Despite the high prevalence and morbidity of osteoarthritis (OA), an effective treatment for
this disease is currently lacking. Restoration of the diseased articular cartilage in patients …

Obesity is a significant risk factor for developing osteoarthritis in weight-bearing and non-
weight-bearing joints. Although the pathogenesis of obesity-associated osteoarthritis is not …