The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

Proton pump inhibitors (PPIs) are used extensively for the treatment of gastric acid-related
disorders, often over the long term, which raises the potential for clinically significant drug …

Importance Precise estimation of the drug metabolism capacity for individual patients is
crucial for adequate dose personalization. Objective To quantify the difference in the …

Objective To evaluate the accumulated information from genetic association studies
investigating the impact of variants of the cytochrome P450 (CYP) 2C19 genotype on the …

Abstract Background Proton pump inhibitors (PPIs) represent drugs of first choice for treating
peptic ulcer, Helicobacter pylori infection, gastrooesophageal reflux disease, nonsteroidal …

Currently, most guidelines on drug–drug interaction (DDI) neither consider the potential
effect of genetic polymorphism in the strength of the interaction nor do they account for the …

Proton pump inhibitors are used extensively for the treatment of gastric acid-related
disorders because they produce a greater degree and longer duration of gastric acid …

Proton pump inhibitors (PPIs) are widely prescribed for the treatment of gastric acid-related
disorders and the eradication of Helicobacter pylori. In addition, they are routinely …

Tacrolimus is a calcineurin inhibitor used to prevent rejection in allogenic solid organ
transplant recipients, which is metabolized in the liver with cytochrome P450 isoforms 3A4 …

We evaluated the effect of prebiotic or probiotic as feed additives on florfenicol kinetic in
broilers feed. Unsexed two hundred, thirty‐five‐day‐old broiler chickens, were put in four …