The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

Abstract Three-dimensional (3D) in vitro models have been used in cancer research as an
intermediate model between in vitro cancer cell line cultures and in vivo tumor. Spherical …

Abstract Background Cancer stem cells (CSCs) are regarded as the cause of tumor
formation and recurrence. The isolation and identification of CSCs could help to develop …

Abstract CD133 (Prominin-1) is considered the most important cancer stem cell (CSC)-
associated marker identified so far, with increased expression in the CSC fraction of a large …

The importance of DNA repair as a resistance mechanism in gliomas, the most aggressive
form of brain tumor, is a clinically relevant topic. Recent studies show that not all cells are …

Cancer stem cells are responsible for tumor progression, metastasis, therapy resistance and
cancer recurrence, doing their identification and isolation of special relevance. Here we …

The cancer stem cell theory hypothesizes that cancer stem cells (CSCs), which possess self-
renewal and other stem cell properties, are regarded as the cause of tumor formation …

The identity of the cells that contribute to brain tumor structure and progression remains
unclear. Mesenchymal stem cells (MSCs) have recently been isolated from normal mouse …

Breast cancer stem cells play a crucial role in the relapse of breast cancers because they
are resistant to a standard chemotherapy and the residual cancer stem cells are able to …

To develop effective therapies for advanced high grade serous ovarian cancer (HGSOC),
understanding mechanisms of recurrence and metastasis is necessary. In this study, we …