Liver fibrosis is a process of excessive accumulation of extracellular matrix caused by liver
injury. Liver fibrosis can progress to cirrhosis or even liver cancer without proper …

Nonalcoholic fatty liver disease (NAFLD), a leading chronic disease worldwide, affects
approximately a quarter of the global population. Nonalcoholic steatohepatitis (NASH) is an …

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent hepatic disease
characterized as lipid accumulation, yet without any approved drug. And development of …

Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease
characterised by aberrant fibroblast/myofibroblast accumulation and excessive collagen …

Background & Aims Liver fibrosis/cirrhosis is significant health burden worldwide, resulting
in liver failure or cancer and accounting for many deaths each year. The pathogenesis of …

Background The study aimed to investigate an association of increased liver fibrosis with
acute myocardial infarction (AMI), and to investigate the mediating effect of serum follistatin …

CCN/WISP (cellular communication network factors, or Wnt-inducted secreted proteins)
family of proteins consists of six extracellular matrix (ECM)-associated proteins that regulate …

The liver has an inherent regenerative capacity via hepatocyte proliferation after mild-to-
modest damage. When hepatocytes exhaust their replicative ability during chronic or severe …

Exposure of articular cartilage to excessive mechanical loading is closely related to the
pathogenesis of osteoarthritis (OA). However, the exact molecular mechanism by which …

Hypertension induces cardiac fibrotic remodelling characterised by the phenotypic switching
of cardiac fibroblasts (CFs) and collagen deposition. We tested the hypothesis that Wnt1 …