The nuclear vitamin D receptor: biological and molecular regulatory properties revealed

MR Haussler, GK Whitfield, CA Haussler… - Journal of bone and …, 1998 - academic.oup.com
IN THE DECADE SINCE THE VITAMIN Dreceptor (VDR) was cloned (1) and recognized as
a member of the superfamily of nuclear receptors that regulate gene expression in a ligand …

Genetics of osteoporosis

SH Ralston, AG Uitterlinden - Endocrine reviews, 2010 - academic.oup.com
Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

Vitamin D receptor polymorphisms and diseases

JM Valdivielso, E Fernandez - Clinica chimica acta, 2006 - Elsevier
The vitamin D endocrine system is central to the control of bone and calcium homeostasis.
Thus, alterations in the vitamin D pathway lead to disturbances in mineral metabolism …

The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal …

C Gross, TR Eccleshall, PJ Malloy… - Journal of Bone and …, 1996 - Wiley Online Library
We examined the association of bone mineral density (BMD) with a polymorphism in the
gene encoding the vitamin D receptor (VDR) that causes a change in the predicted protein …

Molecular nature of the vitamin D receptor and its role in regulation of gene expression

PW Jurutka, GK Whitfield, JC Hsieh… - Reviews in Endocrine …, 2001 - Springer
Clinical and molecular genetic data from the last decade have provided unequivocal
evidence for the obligatory role of the nuclear vitamin D receptor (VDR) in mediating the …

Osteoporosis, genetics and hormones

R Rizzoli, JP Bonjour, SL Ferrari - Journal of molecular …, 2001 - jme.bioscientifica.com
Currently, there is no completely effective therapy available for metastatic
phaeochromocytomas (PCCs) and paragangliomas. In this study, we explore new molecular …

Genetics of osteoporosis

JA Eisman - Endocrine reviews, 1999 - academic.oup.com
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Inadequate vitamin D status: does it contribute to the disorders comprising syndrome 'X'?

BJ Boucher - British Journal of Nutrition, 1998 - cambridge.org
Environmental factors are important in the aetiology of glucose intolerance, type II diabetes
and IHD. The lack of vitamin D, which is necessary for adequate insulin secretion, relates …

Are vitamin D receptor polymorphisms associated with bone mineral density? A meta‐analysis

GS Cooper, DM Umbach - Journal of Bone and Mineral …, 1996 - academic.oup.com
Vitamin D receptor (VDR) polymorphisms have been strongly associated with bone mineral
density (BMD) in some studies but not in others. We used a meta‐analytic approach to …

[PDF][PDF] Role of genetic factors in the pathogenesis of osteoporosis

TL Stewart, SH Ralston - Journal of Endocrinology, 2000 - Citeseer
Osteoporosis is a common disease with a strong genetic component characterised by low
bone mass, microarchitectural deterioration of bone tissue and an increased risk of fracture …