Cervical cancer is a common gynecological malignancy often caused by high-risk human
papillomavirus. There is a paucity of human-derived culture systems to study the cervical …

Focal oncogene amplification and rearrangements drive tumor growth and evolution in
multiple cancer types. We present AmpliconArchitect (AA), a tool to reconstruct the fine …

Simple Summary In human papillomavirus (HPV) associated head and neck squamous cell
carcinomas (HNSCC) s, the HPV genome is commonly found integrated in the human …

Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists
widely in nature and is independent of conventional chromosomes. eccDNA can be divided …

Human papillomavirus (HPV) integration is a critical step in cervical cancer development;
however, the oncogenic mechanism at the genome-wide transcriptional level is still poorly …

Integration of high-risk human papillomavirus (HPV) into the host genome is a crucial event
for the development of cervical cancer, however, the underlying mechanism of HPV …

Virus integration into the human genome occurs frequently and represents a key driving
event in human disease. Many studies have reported viral integration sites (VISs) proximal …

Purpose: Human papillomavirus (HPV) plays a major role in oncogenesis and circular
extrachromosomal DNA (ecDNA) is found in many cancers. However, the relationship …

Simple Summary HPV16 causes approximately 60% of uterine cervical cancer and 95% of
HPV-driven oropharynx cancers. Despite both being HPV-associated, these tumors are very …

Background Integration of human papillomavirus (HPV) into the host genome is a dominant
feature of invasive cervical cancer (ICC), yet the tumorigenicity of cis genomic changes at …