Acid-sensing ion channels in pain and disease
Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …
International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel
S Kellenberger, L Schild, EH Ohlstein - Pharmacological reviews, 2015 - Elsevier
Abstract The epithelial Na+ channel (ENaC) and the acid-sensing ion channels (ASICs) form
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …
Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala
Stimulating presynaptic terminals can increase the proton concentration in synapses.
Potential receptors for protons are acid-sensing ion channels (ASICs), Na+-and Ca2+ …
Potential receptors for protons are acid-sensing ion channels (ASICs), Na+-and Ca2+ …
Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity
CJ Kreple, Y Lu, RJ Taugher… - Nature …, 2014 - nature.com
Acid-sensing ion channel 1A (ASIC1A) is abundant in the nucleus accumbens (NAc), a
region known for its role in addiction. Because ASIC1A has been suggested to promote …
region known for its role in addiction. Because ASIC1A has been suggested to promote …
Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing
Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-
gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs …
gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs …
The function and regulation of acid‐sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC): IUPHAR Review 19
E Boscardin, O Alijevic, E Hummler… - British journal of …, 2016 - Wiley Online Library
Acid‐sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC) are both
members of the ENaC/degenerin family of amiloride‐sensitive Na+ channels. ASICs act as …
members of the ENaC/degenerin family of amiloride‐sensitive Na+ channels. ASICs act as …
[HTML][HTML] Acid-sensing ion channels: focus on physiological and some pathological roles in the brain
Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons
and predominantly expressed in the nervous system. ASICs act as pH sensors leading to …
and predominantly expressed in the nervous system. ASICs act as pH sensors leading to …
Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?
Ischemic brain injury results from complicated cellular mechanisms. The present therapy for
acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen …
acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen …
[HTML][HTML] Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation
HJ Kweon, BC Suh - BMB reports, 2013 - ncbi.nlm.nih.gov
Extracellular acidification occurs not only in pathological conditions such as inflammation
and brain ischemia, but also in normal physiological conditions such as synaptic …
and brain ischemia, but also in normal physiological conditions such as synaptic …
Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2: 1/1: 2 stoichiometry
T Bartoi, K Augustinowski… - Proceedings of the …, 2014 - National Acad Sciences
Acid-sensing ion channels (ASICs) are widely expressed proton-gated Na+ channels
playing a role in tissue acidosis and pain. A trimeric composition of ASICs has been …
playing a role in tissue acidosis and pain. A trimeric composition of ASICs has been …