β-Lactams are the most widely used class of antibiotics. Since the discovery of
benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam …

Covering: 2008–2013. Previous review: 2008, 25, 475 There are a significant number of
natural product (NP) drugs in development. We review the 100 NP and NP-derived …

ABSTRACT The World Health Organization (WHO) has warned that our current arsenal of
antibiotics is not innovative enough to face impending infectious diseases, especially those …

Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously
threatens our capability to treat bacterial diseases, including potentially deadly hospital …

ABSTRACT β-Lactamase-mediated resistance is a growing threat to the continued use of β-
lactam antibiotics. The use of the β-lactam-based serine-β-lactamase (SBL) inhibitors …

The monobactam aztreonam is currently being re-examined as a therapeutic agent in light of
the global spread of carbapenem resistance in aerobic Gram-negative bacilli and …

The emergence of Klebsiella pneumoniae carbapenemases (KPCs), β-lactamases that
inactivate “last-line” antibiotics such as imipenem, represents a major challenge to …

Background Acinetobacter baumannii is an opportunistic human pathogen often associated
with life-threatening infections in the immunocompromised and the critically ill. Strains are …

This study evaluated the in vitro activity of cefepime-zidebactam in comparison with that of
ceftazidime-avibactam and other comparators against clinically significant Gram-negative …

Due to the widespread emergence of resistant bacterial strains, an urgent need for the
development of new antibacterial agents with novel modes of action has emerged. The …