Background Critically ill people may lose fluid because of serious conditions, infections (eg
sepsis), trauma, or burns, and need additional fluids urgently to prevent dehydration or …

Purpose Guidelines recommend crystalloids for fluid resuscitation in sepsis/shock and
switching to albumin in cases where crystalloids are insufficient. We evaluated …

Objective: To determine whether out-of-hospital administration of hypertonic fluids would
improve survival after severe injury with hemorrhagic shock. Background: Hypertonic fluids …

Objectives To describe the profound alterations in host immunity that are produced by major
surgery as demonstrated by experimental and clinical studies, and to evaluate the benefits …

Introduction Worldwide, trauma is a leading cause of death and disability. Haemorrhage is
responsible for up to 40% of trauma deaths. Recent strategies to improve mortality rates …

Background. Individual trials of small-volume resuscitation of 7.5% NaCl (HS) with and
without 6% dextran 70 (HSD) for the treatment of trauma have failed to provide convincing …

Background The leading cause of late mortality after trauma is multiple organ failure
syndrome, due to a dysfunctional inflammatory response early after injury. Preclinical …

Background: The concept of small‐volume resuscitatioin (SVR) using hypertonic solutions
encompasses the rapid infusion of a small dose (4 ml per kg body weight, ie approximately …

The last decade has seen a sea change in the management of major haemorrhage
following traumatic injury. Damage control resuscitation (DCR), a strategy combining the …

Background: The potential to modulate the inflammatory response has renewed interest in
hypertonic saline (HTS) resuscitation of injured patients. However, the effect of the timing of …