BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

M Reig, A Forner, J Rimola, J Ferrer-Fàbrega… - Journal of …, 2022 - Elsevier
There have been major advances in the armamentarium for hepatocellular carcinoma
(HCC) since the last official update of the Barcelona Clinic Liver Cancer prognosis and …

Recent advances in systemic therapy for hepatocellular carcinoma

H Zhang, W Zhang, L Jiang, Y Chen - Biomarker Research, 2022 - Springer
Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumors in
the world. Therapeutic options for advanced HCC are limited. Systemic treatment, especially …

Syringic acid triggers reactive oxygen species–mediated cytotoxicity in HepG2 cells

S Gheena, D Ezhilarasan - Human & experimental …, 2019 - journals.sagepub.com
Hepatocellular carcinoma is the second most common cause of cancer death in the world
and its incidence has dramatically increased worldwide in the past two decades. Syringic …

mRECIST for HCC: performance and novel refinements

JM Llovet, R Lencioni - Journal of hepatology, 2020 - Elsevier
Summary In 2010, modified RECIST (mRECIST) criteria were proposed as a way of
adapting the RECIST criteria to the particularities of hepatocellular carcinoma (HCC). We …

Biomarkers in hepatocellular carcinoma: diagnosis, prognosis and treatment response assessment

F Piñero, M Dirchwolf, MG Pessôa - Cells, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the main cancer-related causes of death
worldwide. Thus, there is a constant search for improvement in screening, diagnosis, and …

EASL clinical practice guidelines: management of hepatocellular carcinoma

PR Galle, A Forner, JM Llovet, V Mazzaferro… - Journal of …, 2018 - Elsevier
Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-
related death globally. Hepatocellular carcinoma represents about 90% of primary liver …

Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a …

AX Zhu, JO Park, BY Ryoo, CJ Yen, R Poon… - The lancet …, 2015 - thelancet.com
Background VEGF and VEGF receptor-2-mediated angiogenesis contribute to
hepatocellular carcinoma pathogenesis. Ramucirumab is a recombinant IgG1 monoclonal …

Tivantinib for second-line treatment of MET-high, advanced hepatocellular carcinoma (METIV-HCC): a final analysis of a phase 3, randomised, placebo-controlled …

L Rimassa, E Assenat, M Peck-Radosavljevic… - The Lancet …, 2018 - thelancet.com
Summary Background Tivantinib (ARQ 197), a selective, oral MET inhibitor, improved
overall survival and progression-free survival compared with placebo in a randomised …

Randomized trials and endpoints in advanced HCC: role of PFS as a surrogate of survival

JM Llovet, R Montal, A Villanueva - Journal of hepatology, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide.
Around half of patients with HCC will receive systemic therapies during their life span. The …

Hepatic arterial infusion of oxaliplatin plus fluorouracil/leucovorin vs. sorafenib for advanced hepatocellular carcinoma

N Lyu, Y Kong, L Mu, Y Lin, J Li, Y Liu, Z Zhang… - Journal of …, 2018 - Elsevier
Background & Aims To compare the overall survival (OS) and disease progression free
survival (PFS) in patients with advanced hepatocellular carcinoma (Ad-HCC) who are …