Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
[HTML][HTML] Recent advances in T-cell receptor repertoire analysis: bridging the gap with multimodal single-cell RNA sequencing
T cells exercise a multitude of functions such as cytotoxicity, secretion of immunomodulating
cytokines or regulation of tolerance, collectively resulting in an effective control of immune …
cytokines or regulation of tolerance, collectively resulting in an effective control of immune …
Pan-peptide meta learning for T-cell receptor–antigen binding recognition
The identification of the mechanisms by which T-cell receptors (TCRs) interact with human
antigens provides a crucial opportunity to develop new vaccines, diagnostics and …
antigens provides a crucial opportunity to develop new vaccines, diagnostics and …
Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases
Monitoring the T cell receptor (TCR) repertoire in health and disease can provide key
insights into adaptive immune responses, but the accuracy of current TCR sequencing …
insights into adaptive immune responses, but the accuracy of current TCR sequencing …
Detection of enriched T cell epitope specificity in full T cell receptor sequence repertoires
High-throughput T cell receptor (TCR) sequencing allows the characterization of an
individual's TCR repertoire and directly queries their immune state. However, it remains a …
individual's TCR repertoire and directly queries their immune state. However, it remains a …
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
ES Ford, K Mayer-Blackwell, L Jing, KJ Laing… - Nature …, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hybrid immunity is more
protective than vaccination or previous infection alone. To investigate the kinetics of spike …
protective than vaccination or previous infection alone. To investigate the kinetics of spike …
OLGA: fast computation of generation probabilities of B-and T-cell receptor amino acid sequences and motifs
Motivation High-throughput sequencing of large immune repertoires has enabled the
development of methods to predict the probability of generation by V (D) J recombination of …
development of methods to predict the probability of generation by V (D) J recombination of …
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key
role in the adaptive antiviral immune response by killing infected cells and facilitating the …
role in the adaptive antiviral immune response by killing infected cells and facilitating the …
An effective COVID-19 vaccine needs to engage T cells
K Sauer, T Harris - Frontiers in immunology, 2020 - frontiersin.org
Ending the current COVID-19 pandemic and preventing recurrence requires the
development of vaccines that provide long-lasting immunity to the causative virus SARS …
development of vaccines that provide long-lasting immunity to the causative virus SARS …
Detecting T cell receptors involved in immune responses from single repertoire snapshots
Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a
vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant …
vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant …