Fundamentals of rhenium-188 radiopharmaceutical chemistry

J Kleynhans, A Duatti, C Bolzati - Molecules, 2023 - mdpi.com
The β− emitter, rhenium-188 (188Re), has long been recognized as an attractive candidate
for targeted cancer radionuclide therapy (TRNT). This transition metal shares chemical …

Current status and progress in using radiolabelled PARP-1 inhibitors for imaging PARP-1 expression in tumours

Q Wang, J Zhang - European Journal of Medicinal Chemistry, 2022 - Elsevier
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme in the DNA repair
process, and the overexpression of PARP-1 in several tumours makes this enzyme a …

Novel Re(I) Complexes as Potential Selective Theranostic Agents in Cancer Cells and In Vivo in Caenorhabditis elegans Tumoral Strains

A Marco, P Ashoo, S Hernández-García… - Journal of Medicinal …, 2024 - ACS Publications
A series of rhenium (I) complexes of the type fac-[Re (CO) 3 (N^ N) L] 0/+, Re1–Re9, was
synthesized, where N^ N= benzimidazole-derived bidentate ligand with an ester …

Recent developments in PET and SPECT radiotracers as radiopharmaceuticals for hypoxia tumors

AT Nguyen, HK Kim - Pharmaceutics, 2023 - mdpi.com
Hypoxia, a deficiency in the levels of oxygen, is a common feature of most solid tumors and
induces many characteristics of cancer. Hypoxia is associated with metastases and strong …

Recent Advances in Bioconjugated Transition Metal Complexes for Cancer Therapy

E Bortolamiol, F Visentin, T Scattolin - Applied Sciences, 2023 - mdpi.com
The introduction of biologically relevant organic moieties in the coordination sphere of
transition metal complexes has recently become a well-established strategy to increase the …

DNA‐Targeted Complexes of Tc and Re for Biomedical Applications

E Palma, JF Santos, C Fernandes… - Chemistry–A European …, 2024 - Wiley Online Library
Due to their favorable chemical features, Re and Tc complexes have been widely used for
the development of new therapeutic agents and imaging probes to solve problems of …

Recent trends and perspectives in rhenium-based nanomaterials for sustainable applications

P Veerakumar, R Pandiyan, SM Chen… - Coordination Chemistry …, 2025 - Elsevier
With the rapid development of modern science and technology, it is necessary to search for
alternative nanostructured materials towards the application of electrochemical (EC) …

1,4,7-Triazacyclononane-Based Chelators for the Complexation of [186Re]Re- and [99mTc]Tc-Tricarbonyl Cores

R Hoerres, HM Hennkens - Inorganic Chemistry, 2023 - ACS Publications
Metal complexes with the general formula [MI (CO) 3 (k3-L)]+, where M= Re, 186Re, or
99mTc and L= 1, 4, 7-triazacyclononane (TACN), NOTA, or NODAGA chelators, have …

Hexadentate technetium-99m bis (thiosemicarbazonato) complexes: synthesis, characterisation and biodistribution

CAA Kelderman, PRWJ Davey, MT Ma, M de Veer… - Dalton …, 2022 - pubs.rsc.org
The syntheses of non-oxido/non-nitrido bis (thiosemicarbazonato) technetium (V) complexes
featuring a series of alkyl and ether substituents is presented. The bis (thiosemicarbazones) …

Ligand-free 99m Tc-polyurea dendrimer complexes: nanoradiotheranostics targeting ovarian cancer

A Cruz, RF Pires, P Raposinho, C Fernandes… - Chemical …, 2024 - pubs.rsc.org
A folic acid-targeted polyurea (PURE) dendrimer was easily radiolabelled with Technetium-
99m (99mTc-PUREG4-FA2) avoiding the use of additional ligands and bioconjugation …