Lysine crotonylation has been discovered in histone and non-histone proteins and found to
be involved in diverse diseases and biological processes, such as neuropsychiatric disease …

In mammals, maintenance of the linear chromosome ends (or telomeres) involves faithful
replication of genetic materials and protection against DNA damage signals, to ensure …

Alzheimer's disease (AD) is the most common form of dementia. The risk of AD increases
with age. Although two of the main pathological features of AD, amyloid plaques and …

Telomeres, at the ends of chromosomes, protect chromosomes from fusion and preserve
genomic stability. However, the molecular mechanisms underlying telomere attrition …

Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to
preserve appropriate self-renewal and differentiation capacities. However, their prolonged in …

Induced pluripotent stem (iPS) cells generated using Yamanaka factors have great potential
for use in autologous cell therapy. However, genomic abnormalities exist in human iPS cells …

Proper telomere length is essential for embryonic stem cell (ESC) self-renewal and
pluripotency. Mouse ESCs (mESCs) sporadically convert to a transient totipotent state …

Inhibition of Mek/Erk signaling by pharmacological Mek inhibitors promotes self-renewal and
pluripotency of mouse embryonic stem cells (ESCs). Intriguingly, Erk signaling is essential …

Ten-eleven translocation (TET) methylcytosine dioxygenases are enzymes that catalyze the
demethylation of 5-methylcytosine on DNA. Through global and site-specific demethylation …

Telomere length homeostasis is essential for genomic stability and unlimited self-renewal of
embryonic stem cells (ESCs). We show that telomere-associated protein Rif1 is required to …