Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

Approximately half of the patients diagnosed with neuroblastoma are classified as having
high-risk disease. This group continues to have inadequate cure rates despite multiagent …

Neuroblastoma has heterogenous clinical presentations that are reflected by several well-
defined clinical factors and biomarkers. Combinations of these clinical and biologic …

DNA-modifying enzymes can specifically identify and repair the DNA damages caused by
intrinsic/extrinsic factors, and they play crucial regulation roles in various cellular activities …

Purpose: Limited effective treatments are currently available for central nervous system
(CNS) metastasis (CM). This is largely driven by the inability of current therapeutics to …

Neuroblastoma is one of the most common pediatric solid tumors that threaten the health of
children, accounting for about 15% of childhood cancer-related mortality in the United …

Ataxia-telangiectasia mutated (ATM) was first discovered in patients with AT (ataxia
telangiectasia), which is characteristic with cerebellar degeneration, immunodeficiency …

Peripheral neuroblastic tumors (neuroblastoma, ganglioneuroblastoma and
ganglioneuroma) are heterogeneous and their diverse and wide range of clinical behaviors …

Although the overall survival rate of B cell acute lymphoblastic leukemia (B-ALL) in
childhood is more than 80%, it is merely 30% in refractory/relapsed and adult patients with B …