Life in Multi-Extreme Environments: Brines, Osmotic and Hydrostatic Pressure─ A Physicochemical View
JM Knop, S Mukherjee, MW Jaworek… - Chemical …, 2022 - ACS Publications
Elucidating the details of the formation, stability, interactions, and reactivity of biomolecular
systems under extreme environmental conditions, including high salt concentrations in …
systems under extreme environmental conditions, including high salt concentrations in …
Effect of high hydrostatic pressure processing on the structure, functionality, and nutritional properties of food proteins: A review
Proteins are important food ingredients that possess both functional and nutritional
properties. High hydrostatic pressure (HHP) is an emerging nonthermal food processing …
properties. High hydrostatic pressure (HHP) is an emerging nonthermal food processing …
Not always sticky: Specificity of protein stabilization by sugars is conferred by protein–water hydrogen bonds
GI Olgenblum, N Carmon, D Harries - Journal of the American …, 2023 - ACS Publications
Solutes added to buffered solutions directly impact protein folding. Protein stabilization by
cosolutes or crowders has been shown to be largely driven by protein–cosolute volume …
cosolutes or crowders has been shown to be largely driven by protein–cosolute volume …
Temperature, hydrostatic pressure, and osmolyte effects on liquid–liquid phase separation in protein condensates: physical chemistry and biological implications
H Cinar, Z Fetahaj, S Cinar, RM Vernon… - … A European Journal, 2019 - Wiley Online Library
Liquid–liquid phase separation (LLPS) of proteins and other biomolecules play a critical role
in the organization of extracellular materials and membrane‐less compartmentalization of …
in the organization of extracellular materials and membrane‐less compartmentalization of …
Protecting Proteins from Desiccation Stress Using Molecular Glasses and Gels
GI Olgenblum, BO Hutcheson, GJ Pielak… - Chemical …, 2024 - ACS Publications
Faced with desiccation stress, many organisms deploy strategies to maintain the integrity of
their cellular components. Amorphous glassy media composed of small molecular solutes or …
their cellular components. Amorphous glassy media composed of small molecular solutes or …
Crowders and cosolvents—major contributors to the cellular milieu and efficient means to counteract environmental stresses
The free energy and conformational landscape of biomolecular systems as well as
biochemical reactions depend not only on temperature and pressure, but also on the …
biochemical reactions depend not only on temperature and pressure, but also on the …
Boosting the kinetic efficiency of formate dehydrogenase by combining the effects of temperature, high pressure and co-solvent mixtures
MW Jaworek, NF Gajardo-Parra, G Sadowski… - Colloids and Surfaces B …, 2021 - Elsevier
The application of co-solvents and high pressure has been shown to be an efficient means
to modify the kinetics of enzyme-catalyzed reactions without compromising enzyme stability …
to modify the kinetics of enzyme-catalyzed reactions without compromising enzyme stability …
Reversible morphological control of tubulin-encapsulating giant liposomes by hydrostatic pressure
M Hayashi, M Nishiyama, Y Kazayama, T Toyota… - Langmuir, 2016 - ACS Publications
Liposomes encapsulating cytoskeletons have drawn much recent attention to develop an
artificial cell-like chemical-machinery; however, as far as we know, there has been no report …
artificial cell-like chemical-machinery; however, as far as we know, there has been no report …
Impact of macromolecular crowding and compression on protein–protein interactions and liquid–liquid phase separation phenomena
We determined the intermolecular interaction potential, V (r), of dense lysozyme solutions,
which governs the spatial distribution of the protein molecules and the location of its liquid …
which governs the spatial distribution of the protein molecules and the location of its liquid …
Hydrostatic pressure increases the catalytic activity of amyloid fibril enzymes
TQ Luong, N Erwin, M Neumann… - Angewandte Chemie …, 2016 - Wiley Online Library
We studied the combined effects of pressure (0.1–200 MPa) and temperature (22, 30, and
38° C) on the catalytic activity of designed amyloid fibrils using a high‐pressure stopped …
38° C) on the catalytic activity of designed amyloid fibrils using a high‐pressure stopped …