Monounsaturated fatty acids in obesity-related inflammation

G Ravaut, A Légiot, KF Bergeron… - International journal of …, 2020 - mdpi.com
Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

The role of stearoyl‐CoA desaturase in obesity, insulin resistance, and inflammation

H Sampath, JM Ntambi - Annals of the New York Academy of …, 2011 - Wiley Online Library
Stearoyl‐CoA desaturase 1 (SCD1) is an essential lipogenic enzyme that has been shown
to play an intrinsic role in the development of obesity and related conditions, such as insulin …

The browning of white adipose tissue: some burning issues

J Nedergaard, B Cannon - Cell metabolism, 2014 - cell.com
Igniting thermogenesis within white adipose tissue (ie, promoting expression and activity of
the uncoupling protein UCP1) has attracted much interest. Numerous" browning agents" …

Stearoyl-CoA desaturase: rogue or innocent bystander?

L Hodson, BA Fielding - Progress in lipid research, 2013 - Elsevier
Different lipid fractions in humans have characteristic fatty acid profiles and these are
maintained partly through diet and to a lesser extent through endogenous synthesis. The …

Aging and dry eye disease

J Ding, DA Sullivan - Experimental gerontology, 2012 - Elsevier
Dry eye disease is a prevalent eye disorder that in particular affects the elderly population.
One of the major causes of dry eye, meibomian gland dysfunction (MGD), shows increased …

Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and …

S An, I Raju, B Surenkhuu, JE Kwon, S Gulati… - The ocular …, 2019 - Elsevier
Purpose To investigate the role of neutrophil extracellular traps (NETs) and NET-associated
proteins in the pathogenesis of oGVHD and whether dismantling of NETs with heparin …

Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

F Oesch, E Fabian, K Guth, R Landsiedel - Archives of Toxicology, 2014 - Springer
The exposure of the skin to medical drugs, skin care products, cosmetics, and other
chemicals renders information on xenobiotic-metabolizing enzymes (XME) in the skin highly …

Sterculic acid: the mechanisms of action beyond stearoyl-CoA desaturase inhibition and therapeutic opportunities in human diseases

R Peláez, A Pariente, Á Pérez-Sala, IM Larráyoz - Cells, 2020 - mdpi.com
In many tissues, stearoyl-CoA desaturase 1 (SCD1) catalyzes the biosynthesis of
monounsaturated fatty acids (MUFAS),(ie, palmitoleate and oleate) from their saturated fatty …

The effect of bioactive aliment compounds and micronutrients on non-alcoholic fatty liver disease

C Munteanu, B Schwartz - Antioxidants, 2023 - mdpi.com
In the current review, we focused on identifying aliment compounds and micronutrients, as
well as addressed promising bioactive nutrients that may interfere with NAFLD advance and …

Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance

H Sampath, JM Ntambi - Journal of Biological Chemistry, 2014 - ASBMB
The skin is the single largest organ in humans, serving as a major barrier to infection, water
loss, and abrasion. The functional diversity of skin requires the synthesis of large amounts of …