Highlights•Allosteric drugs have become an indispensable tool in precision medicine.•Major
targets for allosteric drugs: diversity structures and functions.•Allosteric effects of mutations …

Abstract NAD (P) H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that
catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic …

Highlights•Mutational effects are consistently felt beyond the first shell of
interactions.•Mutations modulate the dynamics and chemical shifts of distal …

Regardless of the diversity of systems, allosteic signalling is found to be always caused by
perturbations. This recurring trait of allostery serves as a foundation for developing different …

Universality of allosteric signaling in proteins, molecular machines, and receptors
complemented by the great advantages of prospected allosteric drugs in the highly specific …

Allosterism is a common phenomenon in protein biochemistry that allows rapid regulation of
protein stability; dynamics and function. However, the mechanisms by which allosterism …

Energy transport during chemical reactions or following photoexcitation in systems of
biological molecules is mediated by numerous interfaces that separate chemical groups and …

The notion that protein function is allosterically regulated by structural or dynamic changes
in proteins has been extensively investigated in several protein domains in isolation. In …

Phosphoglycerate kinase has been a model for the stability, folding cooperativity and
catalysis of a two-domain protein. The human isoform 1 (hPGK1) is associated with cancer …

Signal transducer and activator of transcription 3 (STAT3) plays a key role in promoting
tumor malignant progression. Suppression of hyperactivated STAT3 signaling has emerged …