Recommendations for the management of hemophagocytic lymphohistiocytosis in adults
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
Pediatric hemophagocytic lymphohistiocytosis
SW Canna, RA Marsh - Blood, The Journal of the American …, 2020 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …
[HTML][HTML] Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome
Background T cell mediated hyperinflammatory responses such as cytokine release
syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are …
syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are …
The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage …
B Shakoory, A Geerlinks, M Wilejto, K Kernan… - Annals of the rheumatic …, 2023 - Elsevier
Objective Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation
syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can …
syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can …
Cytokine storm syndrome
Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention
with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions …
with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions …
Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: recommendations from the North American Consortium for Histiocytosis (NACHO)
MB Jordan, CE Allen, J Greenberg… - Pediatric blood & …, 2019 - Wiley Online Library
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …
Histiocytic disorders
KL McClain, C Bigenwald, M Collin… - Nature Reviews …, 2021 - nature.com
The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …
diseases characterized by pathogenic myeloid cells that share histological features with …
The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation
F La Rosée, HC Bremer, I Gehrke, A Kehr, A Hochhaus… - Leukemia, 2020 - nature.com
A subgroup of patients with severe COVID-19 suffers from progression to acute respiratory
distress syndrome and multiorgan failure. These patients present with progressive …
distress syndrome and multiorgan failure. These patients present with progressive …
Macrophage activation syndrome and secondary hemophagocytic lymphohistiocytosis in childhood inflammatory disorders: diagnosis and management
LA Henderson, RQ Cron - Pediatric Drugs, 2020 - Springer
Macrophage activation syndrome (MAS), a form of secondary hemophagocytic
lymphohistiocytosis, is a frequently fatal complication of a variety of pediatric inflammatory …
lymphohistiocytosis, is a frequently fatal complication of a variety of pediatric inflammatory …
Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 cases of a nationwide German registry
S Birndt, T Schenk, B Heinevetter… - Journal of cancer …, 2020 - Springer
Purpose Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory
syndrome emerging from a deregulated immune response due to various triggers. In adults …
syndrome emerging from a deregulated immune response due to various triggers. In adults …