C3 glomerulopathy (C3G) is a rare set of kidney diseases with 2 patterns: C3
glomerulonephritis (C3GN) and dense deposit disease. Pathogenesis of both diseases is …

The complement system is recognized as a major pathogenic or contributing factor in an
ever-growing number of diseases. In addition to inherited factors, autoantibodies to …

Membranoproliferative glomerulonephritis (MPGN) is subdivided into immune-complex-
mediated glomerulonephritis (IC-MPGN) and C3 glomerulopathy (C3G). Classically, MPGN …

The immune complement and the coagulation systems are blood-based proteolytic
cascades that are activated by pathway-specific triggers, based on protein–protein …

C3 glomerulopathy (C3GP) is a group of diseases caused by a deregulated complement
system, which encompasses both dense deposit disease and C3 glomerulonephritis. Renal …

The complement system, an important component of innate immunity, functions as a first-line
host defense in the prevention of microbial infections, clearance of immune complexes, and …

C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic
immune complex membranoproliferative glomerulonephritis (iMPGN). It is increasingly …

Infective endocarditis (IE) is still seen globally with acute kidney injuries remaining a
common complication of the disease. Histological specimens often display either diffuse or …

Autoimmune renal diseases are a group of chronic renal disorders due to dysfunction of the
host immune system with similar immunopathological characteristics of occurrence of …

Abstract C3 glomerulopathy (C3G) is a recently defined pathological entity characterized by
C3 accumulation with absent or scant immunoglobulin deposition, leading to variable …