This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …

For more than 25 years, MDM2 and its homolog MDMX (also known as MDM4) have been
shown to exert oncogenic activity. These two proteins are best understood as negative …

The RAS–ERK pathway is known to play a pivotal role in differentiation, proliferation and
tumour progression. Here, we show that Erk downregulates Forkhead box O 3a (FOXO3a) …

The activities of p53 cover diverse aspects of cell biology, including cell cycle control,
apoptosis, metabolism, fertility, differentiation and cellular reprogramming. Although loss of …

Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53.
Recent studies have shown that Mdm2 is activated in response to a variety of oncogenic …

Over the years, p53 has been shown to sit at the centre of an increasingly complex web of
incoming stress signals and outgoing effector pathways. The number and diversity of stress …

Adherens junctions (AJs) are essential for the maintenance of epithelial homeostasis and a
key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell …

Tumor suppressor p53 plays a central role in preventing tumor formation. The levels and
activity of p53 is under tight regulation to ensure its proper function. Murine double minute 2 …

Aberrant Skp2 signaling has been implicated as a driving event in tumorigenesis. Although
the underlying molecular mechanisms remain elusive, cytoplasmic Skp2 correlates with …

Ubiquitin–proteasome system (UPS) is a selective proteolytic system that is associated with
the expression or function of target proteins and participates in various physiological and …