Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …

Bone tissue engineering has emerged as one of the leading fields in tissue engineering and
regenerative medicine. The success of bone tissue engineering relies on understanding the …

The stiffness of the extracellular matrix (ECM) plays an important role in regulating the
cellular programming. However, the mechanical characteristics of ECM affecting cell …

BMMSCs have drawn great interest in tissue engineering and regenerative medicine
attributable to their multi-lineage differentiation capacity. Increasing evidence has shown …

Accurate animal cell division requires precise coordination of changes in the structure of the
microtubule-based spindle and the actin-based cell cortex. Here, we use a series of …

Background A number of adhesion-mediated signaling pathways and cell-cycle events have
been identified that regulate cell proliferation, yet studies to date have been unable to …

Mechanical forces influence homeostasis in virtually every tissue [1, 2]. Tendon, constantly
exposed to variable mechanical force, is an excellent model in which to study the conversion …

The mechanism by which ECM elasticity induces lineage specification of stem cells has not
been clearly understood. Integrins are well-documented mechanosensors that are …

Extracellular matrix can influence stem cell choices, such as self‐renewal, quiescence,
migration, proliferation, phenotype maintenance, differentiation, or apoptosis. Three aspects …

In stem cell biology, focus has recently turned to the influence of the intrinsic properties of
the extracellular matrix (ECM), such as structural, composition and elasticity, on stem cell …