The Lyme disease spirochete, Borrelia burgdorferi, as a model vector-borne pathogen: insights on regulation of gene and protein expression

B Stevenson - Current opinion in microbiology, 2023 - Elsevier
The Lyme disease spirochete persists in nature through cycles between ticks and
vertebrates. Although the spirochete interacts with numerous, distinct tissues and …

Hitchhiker's Guide to Borrelia burgdorferi

JS Bourgeois, LT Hu - Journal of Bacteriology, 2024 - journals.asm.org
ABSTRACT Don't Panic. In the nearly 50 years since the discovery of Lyme disease, Borrelia
burgdorferi has emerged as an unlikely workhorse of microbiology. Interest in studying host …

Analysis of the Borreliaceae Pangenome Reveals a Distinct Genomic Architecture Conserved Across Phylogenetic Scales

JE Lemieux - The Journal of Infectious Diseases, 2024 - academic.oup.com
The family Borreliaceae contains arthropod-borne spirochetes that cause two widespread
human diseases, Lyme disease and relapsing fever. Lyme disease is a subacute …

A Borrelia burgdorferi LptD homolog is required for flipping of surface lipoproteins through the spirochetal outer membrane

H He, AS Pramanik, SK Swanson… - Molecular …, 2023 - Wiley Online Library
Borrelia spirochetes are unique among diderm bacteria in their lack of lipopolysaccharide
(LPS) in the outer membrane (OM) and their abundance of surface‐exposed lipoproteins …

Identification of a novel transport system in Borrelia burgdorferi that links the inner and outer membranes

HG Bowen, MR Kenedy, DK Johnson… - Pathogens and …, 2023 - academic.oup.com
Borrelia burgdorferi, the spirochete that causes Lyme disease, is a diderm organism that is
similar to Gram-negative organisms in that it contains both an inner and outer membrane …

DnaA modulates the gene expression and morphology of the Lyme disease spirochete

AC Krusenstjerna, N Jusufovic, TC Saylor… - …, 2024 - pmc.ncbi.nlm.nih.gov
All bacteria encode a multifunctional DNA-binding protein, DnaA, which initiates
chromosomal replication. Despite having the most complex, segmented bacterial genome …

Analysis of the Borreliaceae Pangenome Reveals a Conserved Genomic Archictecture Across Phylogenetic Scales

JE Lemieux - bioRxiv, 2024 - biorxiv.org
The Family Borreliaceae contains arthropod-borne spirochetes that cause two widespread
human diseases, Lyme disease (LD) and relapsing fever (RF). LD is a subacute …

A Borrelia burgdorferi LptD Homolog Facilitates Flipping of Surface Lipoproteins Through the Spirochetal Outer Membrane

H He, AS Pramanik, SK Swanson, DK Johnson… - bioRxiv, 2022 - biorxiv.org
Borrelia spirochetes are unique among diderm bacteria in their lack of lipopolysaccharide
(LPS) in the outer membrane (OM) and their abundance of surface-exposed lipoproteins …

The Identification and Characterization of a Novel Transport System in Borrelia burgdorferi

HG Bowen - 2023 - search.proquest.com
Borrelia burgdorferi is a diderm organism with a unique cell ultrastructure. One major
difference between this spirochete and Gram-negative organisms is B. burgdorferi lacks …

Contributions of the Replication Initiator Protein DnaA to Physiology and Virulence of the Lyme Disease Spirochete

A Krusenstjerna - uknowledge.uky.edu
Borrelia burgdorferi, the etiological agent of Lyme disease, is the most prevalent vector-
borne disease in the United States. The spirochetal population is naturally maintained by …