The role of neutrophil extracellular traps in rheumatic diseases
F Apel, A Zychlinsky, EF Kenny - Nature Reviews Rheumatology, 2018 - nature.com
Rheumatic diseases are a collection of disorders defined by the presence of inflammation
and destruction of joints and internal organs. A common feature of these diseases is the …
and destruction of joints and internal organs. A common feature of these diseases is the …
[HTML][HTML] Advances in anti-inflammatory medicinal plants and phytochemicals in the management of arthritis: A comprehensive review
Rheumatoid arthritis (RA) is considered to be an inflammatory disorder whereas OA is not
an overtly inflammatory disorder as RA but certain inflammatory cytokines and periodic …
an overtly inflammatory disorder as RA but certain inflammatory cytokines and periodic …
TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis
There is considerable evidence that osteoclasts are involved in the pathogenesis of focal
bone erosion in rheumatoid arthritis. Tumor necrosis factor-related activation-induced …
bone erosion in rheumatoid arthritis. Tumor necrosis factor-related activation-induced …
[HTML][HTML] Arthritis critically dependent on innate immune system players
H Ji, K Ohmura, U Mahmood, DM Lee, FMA Hofhuis… - Immunity, 2002 - cell.com
K/BxN T cell receptor transgenic mice are a model of inflammatory arthritis, similar to
rheumatoid arthritis. Disease in these animals is focused specifically on the joints but stems …
rheumatoid arthritis. Disease in these animals is focused specifically on the joints but stems …
[HTML][HTML] Complement in the initiation and evolution of rheumatoid arthritis
VM Holers, NK Banda - Frontiers in immunology, 2018 - frontiersin.org
The complement system is a major component of the immune system and plays a central
role in many protective immune processes, including circulating immune complex …
role in many protective immune processes, including circulating immune complex …
[HTML][HTML] K/BxN serum-transfer arthritis as a model for human inflammatory arthritis
AD Christensen, C Haase, AD Cook… - Frontiers in …, 2016 - frontiersin.org
The K/BxN serum-transfer arthritis (STA) model is a murine model in which the
immunological mechanisms occurring in rheumatoid arthritis (RA) and other arthritides can …
immunological mechanisms occurring in rheumatoid arthritis (RA) and other arthritides can …
Critical roles for interleukin 1 and tumor necrosis factor α in antibody-induced arthritis
In spontaneous inflammatory arthritis of K/BxN T cell receptor transgenic mice, the effector
phase of the disease is provoked by binding of immunoglobulins (Igs) to joint surfaces …
phase of the disease is provoked by binding of immunoglobulins (Igs) to joint surfaces …
[HTML][HTML] A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis
FAS Kurreeman, L Padyukov, RB Marques… - PLoS …, 2007 - journals.plos.org
Background Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting∼ 1% of
the population. The disease results from the interplay between an individual's genetic …
the population. The disease results from the interplay between an individual's genetic …
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease
I Matsumoto, M Maccioni, DM Lee, M Maurice… - Nature …, 2002 - nature.com
Arthritis in the K/BxN mouse model results from pathogenic immunoglobulins (Igs) that
recognize the ubiquitous cytoplasmic enzyme glucose-6-phosphate isomerase (GPI). But …
recognize the ubiquitous cytoplasmic enzyme glucose-6-phosphate isomerase (GPI). But …
[HTML][HTML] Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis
X Zhao, NL Okeke, O Sharpe, FM Batliwalla… - Arthritis research & …, 2008 - Springer
Introduction There is increasing evidence that autoantibodies and immune complexes (ICs)
contribute to synovitis in rheumatoid arthritis (RA), yet the autoantigens incorporated in ICs …
contribute to synovitis in rheumatoid arthritis (RA), yet the autoantigens incorporated in ICs …