Anti-obesity drugs: past, present and future

RJ Rodgers, MH Tschöp… - Disease models & …, 2012 - journals.biologists.com
The ideal anti-obesity drug would produce sustained weight loss with minimal side effects.
The mechanisms that regulate energy balance have substantial built-in redundancy, overlap …

Mechanisms of weight regain.

L Busetto, S Bettini, J Makaronidis, CA Roberts… - European journal of …, 2021 - Elsevier
Weight regain following weight loss is frequent problem that people with obesity face. This
weight recidivism is often attributed to the lack of compliance with appropriate food habits …

A prospective open‐label trial of a CBD/THC cannabis oil in dravet syndrome

B McCoy, L Wang, M Zak, S Al‐Mehmadi… - Annals of Clinical …, 2018 - Wiley Online Library
Abstract Introduction Both Δ9 Tetrahydrocannabidiol (THC) and cannabidiol (CBD)
components of cannabis, have been shown to have anticonvulsant effects. Cannabis oils …

The antimicrobial activity of cannabinoids

JA Karas, LJM Wong, OKA Paulin, AC Mazeh… - Antibiotics, 2020 - mdpi.com
A post-antibiotic world is fast becoming a reality, given the rapid emergence of pathogens
that are resistant to current drugs. Therefore, there is an urgent need to discover new …

[HTML][HTML] Lipids in psychiatric disorders and preventive medicine

M Schneider, B Levant, M Reichel, E Gulbins… - Neuroscience & …, 2017 - Elsevier
Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …

CB1 cannabinoid receptors and their associated proteins

AC Howlett, LC Blume… - Current medicinal …, 2010 - ingentaconnect.com
CB1 receptors are G-protein coupled receptors (GPCRs) abundant in neurons, in which they
modulate neurotransmission. The CB1 receptor influence on memory and learning is well …

Cannabidiol attenuates the appetitive effects of Δ9-tetrahydrocannabinol in humans smoking their chosen cannabis

CJA Morgan, TP Freeman, GL Schafer… - …, 2010 - nature.com
Worldwide cannabis dependence is increasing, as is the concentration of Δ 9-
tetrahydrocannabinol (THC) in street cannabis. At the same time, the concentration of the …

Effects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: a randomized, double-blind, placebo-controlled, human …

M Farokhnia, GR McDiarmid, MN Newmeyer… - Translational …, 2020 - nature.com
As perspectives on cannabis continue to shift, understanding the physiological and
behavioral effects of cannabis use is of paramount importance. Previous data suggest that …

Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits

BK Lau, D Cota, L Cristino, SL Borgland - Neuropharmacology, 2017 - Elsevier
The endocannabinoid system has emerged as a key player in the control of eating.
Endocannabinoids, including 2-arachidonoylglycerol (2-AG) and anandamide (AEA) …

Ghrelin and food reward

O Al Massadi, R Nogueiras, C Dieguez, JA Girault - Neuropharmacology, 2019 - Elsevier
Food intake is tightly regulated by homeostatic and reward mechanisms and the adequate
function of both is necessary for the proper maintenance of energy balance. Ghrelin impacts …