Non-lypolitic esterases are carboxylester hydrolases with preference for the hydrolysis of
water-soluble esters bearing short-chain acyl residues. The potential of esterases as …

<? xm-replace_text {Heading}?> Abstract Chiral chemicals are a group of important chiral
synthons for the synthesis of a series of pharmaceuticals, agrochemicals, and fine …

Optically pure compounds are important in the synthesis of fine chemicals. Using directed
evolution of enzymes to obtain biocatalysts that can selectively produce high‐value chiral …

The enantioselective hydrolysis of ortho‐chloromandelonitrile with nitrilase is one of the
most attractive approaches to prepare (R)‐ortho‐chloromandelic acid. To date, efforts to …

Abstract tert-Butyl (S)-6-chloro-5-hydroxy-3-oxohexanoate ((S)-CHOH) is a valuable chiral
synthon, which is used for the synthesis of the cholesterol-lowering drugs atorvastatin and …

A versatile keto ester reductase CgKR1, exhibiting a broad substrate spectrum, was
obtained from Candida glabrata by genome data mining. It showed the highest activity …

The transition between dormant and active Mycobacterium tuberculosis infection requires
reorganization of its lipid metabolism and activation of a battery of serine hydrolase …

Serine hydrolases have diverse intracellular substrates, biological functions, and structural
plasticity, and are thus important for biocatalyst design. Amongst serine hydrolases, the …

A “polarity scanning” strategy was successfully performed in the present study to identify the
critical residues for inverting the stereoselectivity of R-selective nitrilase as the product with …

Microbial carboxylesterases are important biocatalysts that selectively hydrolyze an
extensive range of esters. Here, we report the biochemical and structural characterization of …