Organisms have evolved mechanisms to cope with and adapt to unexpected challenges and
harsh conditions. Unfolded or misfolded proteins represent a threat for cells and organisms …

Hereditary spastic paraplegia (HSP) is a group of inherited neurodegenerative conditions
that share a characteristic feature of degeneration of the longest axons within the …

C. elegans and D. rerio expressing mutant TAR DNA Binding Protein 43 (TDP-43) are
powerful in vivo animal models for the genetics and pharmacology of amyotrophic lateral …

Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimeric GTPase, which plays a
critical role in protein synthesis regulation. eIF2-GTP binds Met-tRNAi to form the eIF2-GTP• …

Inactivation of the tumor suppressor protein p53 by mutagenesis, chemical modification,
protein-protein interaction, or aggregation has been associated with different human …

Due to the lack of relevant animal models, development of effective treatments for human
mitochondrial diseases has been limited. Here we establish a rapid, yeast-based assay to …

The prions (infectious proteins) of Saccharomyces cerevisiae are proteins acting as genes,
by templating their conformation from one molecule to another in analogy to DNA templating …

Recent studies have proposed that nucleic acids act as potential cofactors for protein
aggregation and prionogenesis. By means of sedimentation, transmission electron …

Most prions (infectious proteins) are self‐propagating amyloids (filamentous protein
multimers), and have been found in both mammals and fungal species. The prions [URE3] …

A misfolded form of the prion protein (PrP) is the primary culprit in mammalian prion
diseases. It has been shown that nucleic acids catalyze the misfolding of cellular PrP into a …