The modern antiretroviral treatment of human immunodeficiency virus (HIV-1) infection has
considerably lowered the incidence of opportunistic infections. With the exception of the …

Neurological involvement in HIV is often associated with cognitive impairment. Although
severe and progressive neurocognitive impairment has become rare in HIV clinics in the era …

Background. Occasional cases of viral escape in cerebrospinal fluid (CSF) despite
suppression of plasma human immunodeficiency virus type 1 (HIV-1) RNA have been …

Compartmentalized HIV-1 replication within the central nervous system (CNS) likely
provides a foundation for neurocognitive impairment and a potentially important tissue …

HIV-associated central nervous system (CNS) injury continues to be clinically significant in
the modern era of HIV infection and therapy. A substantial proportion of patients with …

With the introduction of combination antiretroviral therapy AIDS dementia complex or HIV-
associated dementia, as it was termed later, largely disappeared in clinical practice …

Prevention and treatment of HAND requires strategies aimed at suppressing CNS HIV
replication and effects of systemic and CNS inflammation in aging and substance-abusing …

Monocytes and macrophages play critical roles in HIV transmission, viral spread early in
infection, and as a reservoir of virus throughout infection. There has been a recent …

ABSTRACT HIV continues to be a global health crisis with more than 34 million people
infected worldwide (UNAIDS: Report on the Global AIDS Epidemic 2010, Geneva, World …

HIV-1 invades the central nervous system (CNS) in the context of acute infection, persists
thereafter in the absence of treatment, and leads to chronic intrathecal immunoactivation that …