A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

While multiple theories have been put forth regarding the origin of schizophrenia, by far the
vast majority of evidence points to the neurodevelopmental model in which developmental …

Single-nuclei RNA sequencing characterizes cell types at the gene level. However,
compared to single-cell approaches, many single-nuclei cDNAs are purely intronic, lack …

Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) are related tyrosine
kinases that have important cellular functions, primarily through regulation of the …

Genetic risk factors for autism spectrum disorder (ASD) have yet to be fully elucidated.
Postzygotic mosaic mutations (PMMs) have been implicated in several neurodevelopmental …

Local protein synthesis regulates the turning of growth cones to guidance cues, yet little is
known about which proteins are synthesized or how they contribute to directional steering …

Axon-dendrite polarity is a cardinal feature of neuronal morphology essential for information
flow. Here we report a differential distribution of GSK-3β activity in the axon versus the …

Nonsyndromic cleft lip with or without a cleft palate (NSCL/P) is among the most common
human congenital birth defects and imposes a substantial physical and financial burden on …

Growth cones, found at the tip of axonal projections, are the sensory and motile organelles
of developing neurons that enable axon pathfinding and target recognition for precise wiring …

Developing neurons use a combination of guidance cues to assemble a functional neural
network. A variety of proteins immobilized within the extracellular matrix (ECM) provide …