Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets
MK Crow - Annals of the rheumatic diseases, 2023 - ard.bmj.com
Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …
Autophagy balances inflammation in innate immunity
Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One
of the pivotal contributions of autophagy in immunity is the cell autonomous control of …
of the pivotal contributions of autophagy in immunity is the cell autonomous control of …
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
J Bentham, DL Morris, DS Cunninghame Graham… - Nature …, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …
Emerging concepts of type I interferons in SLE pathogenesis and therapy
Type I interferons have been suspected for decades to have a crucial role in the
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …
[HTML][HTML] Transancestral mapping and genetic load in systemic lupus erythematosus
CD Langefeld, HC Ainsworth, DSC Graham… - Nature …, 2017 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using …
ethnic disparities. We report a large transancestral association study of SLE using …
Autophagy and inflammation
Y Matsuzawa-Ishimoto, S Hwang… - Annual review of …, 2018 - annualreviews.org
The cellular degradative pathway of autophagy has a fundamental role in immunity. Here,
we review the function of autophagy and autophagy proteins in inflammation. We discuss …
we review the function of autophagy and autophagy proteins in inflammation. We discuss …
Autophagy in infection, inflammation and immunity
Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity.
Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …
Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …
Complement genes contribute sex-biased vulnerability in diverse disorders
N Kamitaki, A Sekar, RE Handsaker, H De Rivera… - Nature, 2020 - nature.com
Many common illnesses, for reasons that have not been identified, differentially affect men
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) …
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) …
[HTML][HTML] Exploring the Role of Autophagy-Related Gene 5 (ATG5) Yields Important Insights Into Autophagy in Autoimmune/Autoinflammatory Diseases
Autophagy is a highly conserved process that degrades certain intracellular contents in both
physiological and pathological conditions. Autophagy-related proteins (ATG) are key players …
physiological and pathological conditions. Autophagy-related proteins (ATG) are key players …
Oral lichen planus: A disease or a spectrum of tissue reactions? Types, causes, diagnostic algorhythms, prognosis, management strategies
Oral lichen planus and lichenoid lesions comprise a group of disorders of the oral mucosa
that likely represent a common reaction pattern to 1 or more unknown antigens. The …
that likely represent a common reaction pattern to 1 or more unknown antigens. The …