Introduction The circulation of large amounts of dehydroepiandrosterone (DHEA) and its
sulfated derivative (DHEA‐S) suggests a physiological role in human physiology. In the …

Dehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA), secreted by the adrenal
cortex, gastrointestinal tract, gonads, and brain, and its sulfated metabolite DHEA-S are the …

Diabetic encephalopathy, characterized by impaired cognitive functions and neurochemical
and structural abnormalities, may involve direct neuronal damage caused by intracellular …

Alongside increased proteolysis, the inability to repair damaged skeletal muscle is a
characteristic feature of uncontrolled diabetes. This study evaluates the role of oxidative …

Evidence obtained over the past two decades shows that reactive oxygen species (ROS) are
involved in brain lesions, including those due to cerebral ischemia-reperfusion. The …

Bisphenol A (BPA), an estrogenic and endocrine disrupting agent, is widely used in
manufacturing of polycarbonate plastics and epoxy resins. BPA and other endocrine …

Evidence suggests that neuroactive steroids may be candidate modulators of schizophrenia
pathophysiology and therapeutics. We therefore investigated neuroactive steroid levels in …

Neuron viability and defense against neurodegenerative disease can be achieved by
targeting mitochondrial function to reduce oxidative stress, increase mitochondrial defense …

Estrogens are potent neuroprotective hormones and mitochondria are the site of cellular life–
death decisions. As such, it is not surprising that we and others have shown that estrogens …

Oxidative stress, bioenergetic failure and mitochondrial dysfunction are all implicated in the
etiology of neurodegenerative diseases such as Alzheimer's disease (AD). The …