Despite nearly three decades of advances in the management of rheumatoid arthritis (RA), a
substantial minority of patients are exposed to multiple DMARDs without necessarily …

Rheumatoid arthritis (RA) is a systemic auto-immune disease principally effecting synovial
joints. RA is characterized by immune cell infiltration in the joint. The presence of …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation,
which affects approximately 1% of the population. The benefit of early recognition and …

Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation.
The presence of autoantibodies in the sera of RA patients has provided many clues to the …

Objectives Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies
(ACPAs) appear before disease onset and are associated with bone destruction. We aimed …

Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed,
infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph …

The presence of disease-specific autoantibody responses and the efficacy of B cell-targeting
therapies in rheumatoid arthritis (RA) indicate a pivotal role for B cells in disease …

Autoimmune responses against posttranslationally modified antigens are a hallmark of
several autoimmune diseases. For example, antibodies against citrullinated protein antigens …

Immunology, already a discipline in its own right, has become a major part of many different
medical fields. However, its relationship to orthopedics and trauma surgery has …