The past several years have witnessed an increased presence of control theoretic concepts
in synthetic biology. This review presents an organized summary of how these control …

Receptor tyrosine kinase (RTK) signaling pathways control multiple cellular decisions in
metazoans, often by regulating the expression of downstream genes. In Drosophila …

Summary The EGF-stimulated ERK/MAPK pathway is a key conduit for cellular proliferation
signals and a therapeutic target in many cancers. Here, we characterize two central …

The behavior of gene modules in complex synthetic circuits is often unpredictable 1, 2, 3, 4.
After joining modules to create a circuit, downstream elements (such as binding sites for a …

Just like in many engineering systems, impedance-like effects, called retroactivity, arise at
the interconnection of biomolecular circuits, leading to unexpected changes in a circuit's …

The ability to link systems together such that they behave as predicted once they interact
with each other is an essential requirement for the forward-engineering of robust synthetic …

The extracellular signal-regulated kinase (ERK) pathway leads to activation of the effector
molecule ERK, which controls downstream responses by phosphorylating a variety of …

The notion of feedback is fundamental for understanding signal transduction networks.
Feedback loops attenuate or amplify signals, change the network dynamics and modify the …

The Drosophila blastoderm embryo is a classic model for the study of the genetics of pattern
formation. In recent years, quantitative empirical approaches have been employed …

The transcriptional repressor Capicua (Cic) controls multiple aspects of Drosophila
embryogenesis and has been implicated in vertebrate development and human diseases …