Advances in molecular diagnosis of tuberculosis

E MacLean, M Kohli, SF Weber, A Suresh… - Journal of clinical …, 2020 - Am Soc Microbiol
Molecular tests for tuberculosis (TB) have the potential to help reach the three million people
with TB who are undiagnosed or not reported each year and to improve the quality of care …

Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance

M Kohli, I Schiller, N Dendukuri… - Cochrane Database …, 2018 - cochranelibrary.com
Background Tuberculosis (TB) is the world's leading infectious cause of death.
Extrapulmonary TB accounts for 15% of TB cases, but the proportion is increasing, and over …

Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis

TE Sweeney, L Braviak, CM Tato… - The Lancet Respiratory …, 2016 - thelancet.com
Background Active pulmonary tuberculosis is difficult to diagnose and treatment response is
difficult to effectively monitor. A WHO consensus statement has called for new non-sputum …

Four-gene pan-African blood signature predicts progression to tuberculosis

S Suliman, EG Thompson, J Sutherland… - American journal of …, 2018 - atsjournals.org
Rationale: Contacts of patients with tuberculosis (TB) constitute an important target
population for preventive measures because they are at high risk of infection with …

Development, roll-out and impact of Xpert MTB/RIF for tuberculosis: what lessons have we learnt and how can we do better?

H Albert, RR Nathavitharana, C Isaacs… - European …, 2016 - Eur Respiratory Soc
The global roll-out of Xpert MTB/RIF (Cepheid Inc., Sunnyvale, CA, USA) has changed the
diagnostic landscape of tuberculosis (TB). More than 16 million tests have been performed …

The pathogenesis of tuberculous meningitis

AG Davis, UK Rohlwink, A Proust… - Journal of leukocyte …, 2019 - academic.oup.com
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …

Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis

E Petruccioli, TJ Scriba, L Petrone… - European …, 2016 - Eur Respiratory Soc
New approaches to control the spread of tuberculosis (TB) are needed, including tools to
predict development of active TB from latent TB infection (LTBI). Recent studies have …

Update on tuberculosis biomarkers: from correlates of risk, to correlates of active disease and of cure from disease

D Goletti, MR Lee, JY Wang, N Walter… - …, 2018 - Wiley Online Library
Tuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global
health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB‐BM) would …

Tuberculosis diagnostics in 2015: landscape, priorities, needs, and prospects

M Pai, M Schito - The Journal of infectious diseases, 2015 - academic.oup.com
In 2015, tuberculosis remains a major global health problem, and drug-resistant tuberculosis
is a growing threat. Although tuberculosis diagnosis in many countries is still reliant on older …

Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults

M Kohli, I Schiller, N Dendukuri, M Yao… - Cochrane Database …, 2021 - cochranelibrary.com
Background Xpert MTB/RIF Ultra (Xpert Ultra) and Xpert MTB/RIF are World Health
Organization (WHO)‐recommended rapid nucleic acid amplification tests (NAATs) widely …