Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Abstract Cytochrome P450 2D6 (CYP2D6) plays an important role in the metabolism and
bioactivation of about 25% of clinically used drugs including many antidepressants …

CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in
the 1970s. This is because of its involvement in the metabolism of more than 25% of the …

The current 'fixed-dosage strategy'approach to medicine, means there is much inter-
individual variation in drug response. Pharmacogenetics is the study of how inter-individual …

Purpose The CYP3A and CYP2D6 enzymes play a major role in converting tamoxifen to its
active metabolites. CYP3A is a highly inducible enzyme, regulated mainly by pregnane X …

The influence of cytochrome P450 2D6 (CYP2D6) genetic variability was examined in
psychiatric inpatients by evaluating adverse drug events (ADEs), hospital stays, and total …

Background. Codeine analgesia is wholly or mostly due to its metabolism to morphine by the
cytochrome P450 enzyme CYP2D6, which shows significant genetic variation in activity. The …

Background and Objectives The genetically polymorphic cytochrome P450 enzymes 2C19
(CYP2C19) and 2D6 (CYP2D6) contribute to the metabolism of about 30% of all drugs. For …

Objective The CYP2D6 genotype is a major determinant of interindividual differences in
metoprolol plasma clearance. Cytochrome P450 2D6 (CYP2D6) poor metabolizers exhibit 3 …

Objective This evaluation focuses on polymorphisms of the cytochrome-P450 (CYP)
isoenzymes 2C9, 2C19 and 2D6 and their association with plasma concentrations within a …