Based on its clinical benefits, Trikafta—the combination of folding correctors VX-661
(tezacaftor), VX-445 (elexacaftor), and the gating potentiator VX-770 (ivacaftor)—was FDA …

Cystic fibrosis (CF) is a genetic disease caused by mutations in the CFTR gene. Although
viral respiratory tract infections are, in general, more severe in patients with CF compared …

Cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that plays a crucial
role in various human organs, including the respiratory and digestive systems. Dysfunctional …

In cystic fibrosis (CF), the deletion of phenylalanine 508 (F508del) in the CF transmembrane
conductance regulator (CFTR) leads to misfolding and premature degradation of the mutant …

Cystic fibrosis (CF) is caused by defects of the cystic fibrosis transmembrane conductance
regulator (CFTR) gene. CFTR-modulating drugs may overcome specific defects, such as the …

Cystic fibrosis (CF) is caused by defects of the cystic fibrosis transmembrane conductance
regulator (CFTR) gene. CFTR-modulating drugs may overcome specific defects, such as the …

Remarkable progress in CFTR research has led to the therapeutic development of
modulators that rescue the basic defect in cystic fibrosis. There is continuous interest in …

Clinical and experimental results with inhaled sodium bicarbonate as an adjuvant therapy in
cystic fibrosis (CF) are promising due to its mucolytic and bacteriostatic properties, but its …

The aim of this review article is to collate recent contributions of proteomic studies to cystic
fibrosis transmembrane conductance regulator (CFTR) biology. We summarize advances …

The greatest challenge of 21st century biology is to fully understand mechanisms of disease
to drive new approaches and medical innovation. Parallel to this is the huge biomedical …