The major functions of the cell nucleus, including transcription, pre-mRNA splicing and
ribosome assembly, have been studied extensively by biochemical, genetic and molecular …

Cytokine loci undergo changes in chromatin structure when naive CD4+ T cells differentiate
into Th1 or Th2 cells and have also been examined for regulatory sequences underlying …

We generated transgenic mice in which red, green, yellow, or cyan fluorescent proteins
(together termed XFPs) were selectively expressed in neurons. All four XFPs labeled …

SATB1 (special AT-rich sequence binding protein 1) organizes cell type–specific nuclear
architecture by anchoring specialized DNA sequences and recruiting chromatin remodeling …

The linear array of nucleosomes that comprises the primary structure of chromatin is folded
and condensed to varying degrees in nuclei and chromosomes forming 'higher order …

Heterochromatin mediates many diverse functions in the cell nucleus, including centromere
function, gene silencing and nuclear organization. The condensed structure of …

It has become apparent that the clinical success anticipated in the field of gene therapy has
been limited by progress in several of the fundamental areas of genetics, molecular and …

The Th2 cytokine genes IL4, IL5, and IL13 are clustered and expressed in a cell lineage-
specific manner. We investigated the global locus-specific regulation of these genes using …

Pax5 is an essential regulator of B cell identity and function. Here, we used transgenesis
and deletion mapping to identify a potent enhancer in intron 5 of the Pax5 locus. This …

The ability to engineer the mouse genome has profoundly transformed biomedical research.
During the last decade, conventional transgenic and gene knockout technologies have …