In silico identification and evaluation of new Trypanosoma cruzi trypanothione reductase (TcTR) inhibitors obtained from natural products database of the Bahia semi …

VG da Paixão, SS da Rocha Pita - Computational Biology and Chemistry, 2019 - Elsevier
Abstract Trypanosoma cruzi Trypanothione Reductase (TcTR) is one of the therapeutic
targets studied in the development of new drugs against Chagas' disease. Due to its …

Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release

GE Stutzmann, R Dahl, CH Kaiho - US Patent 10,011,578, 2018 - Google Patents
Disclosed herein are methods and compositions comprising compounds capable of
normalizing neuronal calcium dys homeostasis. Also disclosed are methods comprising …

Furanyl-imine and thiofuranyl-imine compounds for stabilizing ryanodine receptors from aberrant levels of calcium release

GE Stutzmann, R Dahl, CH Kaiho - US Patent 9,725,429, 2017 - Google Patents
Page 2 capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are
methods comprising these compounds for treating neuronal or neurological disorders …