Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new
treatments and biomarkers in oncology. PDX models are used to address clinically relevant …

Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly
supplanting long-established traditional cell lines as preferred models for conducting basic …

Although metastasis remains the cause of most cancer-related mortality, mechanisms
governing seeding in distal tissues are poorly understood. Here, we establish a robust …

High levels of the imprinted gene pleckstrin homology like domain family A member 2
(PHLDA2) correlate with tumor progression in several malignancies. Here, we investigated …

Optimal patient stratification is of utmost importance in the era of personalized medicine.
Prediction of individual treatment responses by functional ex vivo assays requires model …

Cancer is a very heterogeneous disease, displaying heterogeneity between patients (inter-
tumoral heterogeneity) and heterogeneity within a patient (intra-tumoral heterogeneity) …

Background and Objective Endometrial cancer (EC) is a common gynecological malignancy
worldwide. Despite advances in the development of strategies for treating EC, prognosis of …

Transketolase (TKT) is an enzyme that is ubiquitously expressed in all living organisms and
has been identified as an important regulator of cancer. Recent studies have shown that the …

Therapeutic innovation for human papilloma virus‐related (HPV+) head and neck squamous
cell carcinomas (HNSCCs) is impaired by inadequate preclinical models and the absence of …

Heat shock protein family A member 8 (HSPA8) participates in the folding or degradation of
misfolded proteins under stress and plays critical roles in cancer. In this study, we …