The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …

An ideal animal model of atherosclerosis resembles human anatomy and pathophysiology
and has the potential to be used in medical and pharmaceutical research to obtain results …

The perpetuation of inflammation is an important pathophysiological contributor to the global
medical burden. Chronic inflammation is promoted by non-programmed cell death,; …

Advanced atherosclerotic lesions contain senescent cells, but the role of these cells in
atherogenesis remains unclear. Using transgenic and pharmacological approaches to …

Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

Atherosclerosis is a leading cause of vascular diseases worldwide. Whereas antioxidative
therapy has been considered promising for the treatment of atherosclerosis in view of a …

Antisense oligonucleotides (ASOs) are promising tools for gene silencing and have been
exploited as therapeutics for human disease. However, delivery of therapeutic ASOs to …

WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcome Study) and colchicine
trials suggest an important role of inflammasomes and their major product IL-1β (interleukin …