For decades, immunologists have studied the role of circulating immune cells in host
protection, with a more recent appreciation of immune cells resident within the tissue …

Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …

Tissue damage and inflammation are important triggers for regeneration and fibrosis. Tissue
damage not only induces inflammation in general, it also determines the type and …

Systemic sclerosis (scleroderma) is an autoimmune‐triggered chronic fibrosing disease that
affects the skin and many other organs. Its pathophysiology is complex and involves an early …

Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …

Rationale: An exaggerated or persistent inflammatory activation after myocardial infarction
(MI) leads to maladaptive healing and subsequent remodeling of the left ventricle. Foxp3+ …

Macrophages are found in close proximity with collagen-producing myofibroblasts and
indisputably play a key role in fibrosis. They produce profibrotic mediators that directly …

Fibrosis is defined by the overgrowth, hardening, and/or scarring of various tissues and is
attributed to excess deposition of extracellular matrix components including collagen …