In the 40 years since the discovery of natural killer (NK) cells, it has been well established
that these innate lymphocytes are important for early and effective immune responses …

Although the signaling pathways involved in normal liver regeneration have been well
characterized, less has been done for livers affected by chronic tissue damage. These …

In this paper we present an overview of agent-based models that are used to simulate
mechanical and physiological phenomena in cells and tissues, and we discuss underlying …

With more than 240 million people infected, hepatitis B virus (HBV) is a major health
concern. The inability to mimic the complexity of the liver using cell lines and regular primary …

We developed an in vitro model system where induced pluripotent stem cells (iPSCs)
differentiate into 3-dimensional human hepatic organoids (HOs) through stages that …

Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load
and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for …

Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In
addition, currently available in vitro methods do not allow for the estimation of hepatotoxic …

Bile duct ligation (BDL) is an experimental procedure that mimics obstructive cholestatic
disease. One of the early consequences of BDL in rodents is the appearance of so‐called …

Cholestasis is a common complication in liver diseases that triggers a proliferative response
of the biliary tree. Bile duct ligation (BDL) is a frequently used model of cholestasis in …

Rational development of more physiologic in vitro models includes the design of robust and
flexible 3D-microtissue-based multi-tissue devices, which allow for tissue–tissue …