The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila
melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called …

Gametes are highly specialized cell types produced by a complex differentiation process.
Production of viable oocytes requires a series of precise and coordinated molecular events …

Tissue flow during morphogenesis is commonly driven by local constriction of cell cortices,
which is caused by the activation of actomyosin contractility. This can lead to long-range …

Tissues use numerous mechanisms to change shape during development. The Drosophila
egg chamber is an organ-like structure that elongates to form an elliptical egg. During …

Similar to the mammalian intestine, the Drosophila adult midgut has resident stem cells that
support growth and regeneration. How the niche regulates intestinal stem cell activity in both …

Basement membranes (BMs) are specialized extracellular matrices that are essential for
epithelial structure and morphogenesis. However, little is known about how BM proteins are …

Basement membranes (BMs) are planar protein networks that support epithelial function.
Regulated changes to BM architecture can also contribute to tissue morphogenesis, but how …

The basement membrane is a specialized extracellular matrix (ECM) that is crucial for the
development of epithelial tissues and organs. In Drosophila, the mechanical properties of …

The vertebrate Fat cadherins comprise a small gene family of four members, Fat1–Fat4, all
closely related in structure to Drosophila ft and ft2. Over the past decade, knock‐out mouse …

Collective migration of epithelial cells underlies diverse tissue-remodeling events, but the
mechanisms that coordinate individual cell migratory behaviors for collective movement are …