Bacterial synthetic biology: tools for novel drug discovery
Introduction Bacterial synthetic biology has provided powerful tools to revolutionize the drug
discovery process. These tools can be harnessed to generate bacterial novel …
discovery process. These tools can be harnessed to generate bacterial novel …
Recent advances in modelling Shigella infection
Shigella is an important human-adapted pathogen which contributes to a large global
burden of diarrhoeal disease. Together with the increasing threat of antimicrobial resistance …
burden of diarrhoeal disease. Together with the increasing threat of antimicrobial resistance …
Engineering probiotic Escherichia coli Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system
M Fang, R Zhang, C Wang, Z Liu, M Fei… - Applied and …, 2024 - journals.asm.org
Many multidrug-resistant (MDR) bacteria have evolved through the accumulation of
antibiotic resistance genes (ARGs). Although the potential risk of probiotics as reservoirs of …
antibiotic resistance genes (ARGs). Although the potential risk of probiotics as reservoirs of …
An automated microscopy workflow to study Shigella–neutrophil interactions and antibiotic efficacy in vivo
A Lensen, MC Gomes… - Disease models & …, 2023 - journals.biologists.com
Shigella are Gram-negative bacterial pathogens responsible for bacillary dysentery (also
called shigellosis). The absence of a licensed vaccine and widespread emergence of …
called shigellosis). The absence of a licensed vaccine and widespread emergence of …
Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri
Shigella flexneri is a human-adapted pathovar of Escherichia coli that can invade the
intestinal epithelium, causing inflammation and bacillary dysentery. Although an important …
intestinal epithelium, causing inflammation and bacillary dysentery. Although an important …
De Novo Synthesis of a Conjugative System from Human Gut Metagenomic Data for Targeted Delivery of Cas9 Antimicrobials
Metagenomic sequences represent an untapped source of genetic novelty, particularly for
conjugative systems that could be used for plasmid-based delivery of Cas9-derived …
conjugative systems that could be used for plasmid-based delivery of Cas9-derived …
A New Insight into Phage Combination Therapeutic Approaches Against Drug-Resistant Mixed Bacterial Infections
M Rahimian, D Jafari-Gharabaghlou, E Mohammadi… - PHAGE, 2024 - liebertpub.com
Rising antibiotic resistance among bacterial pathogens has become a substantial health
issue for human civilization. The emergence of these pathogens in high-risk diseases such …
issue for human civilization. The emergence of these pathogens in high-risk diseases such …
From resistance to remedy: the role of clustered regularly interspaced short palindromic repeats system in combating antimicrobial resistance—a review
The growing challenge of antimicrobial resistance (AMR) poses a significant and increasing
risk to public health worldwide, necessitating innovative strategies to restore the efficacy of …
risk to public health worldwide, necessitating innovative strategies to restore the efficacy of …
The untapped potential of phage model systems as therapeutic agents
J Romeyer Dherbey, F Bertels - Virus Evolution, 2024 - academic.oup.com
With the emergence of widespread antibiotic resistance, phages are an appealing
alternative to antibiotics in the fight against multidrug-resistant bacteria. Over the past few …
alternative to antibiotics in the fight against multidrug-resistant bacteria. Over the past few …
Bacteriophage as cargo and its application in nanomedicine
VK Arivarasan, C Consul - Progress in Molecular Biology and Translational …, 2023 - Elsevier
Bacteriophages are viruses that infect the bacteria. However, different studies conducted on
the same display a wide range of applications in terms of therapeutic purposes. The …
the same display a wide range of applications in terms of therapeutic purposes. The …