This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …

Intercellular anchoring junctions are highly specialized regions of the plasma membrane
where members of the cadherin family of transmembrane adhesion molecules on opposing …

Adherens junctions, which play a central role in intercellular adhesion, comprise clusters of
type I classical cadherins that bind via extracellular domains extended from opposing cell …

Tyrosine kinase inhibitors (TKIs) are highly effective in treatment of chronic myeloid
leukemia (CML) but do not eliminate leukemia stem cells (LSCs), which remain a potential …

Synapse formation involves reciprocal interactions between cells resulting in formation of a
structure optimized for efficient information transfer. Recent work has implicated constituents …

Many cell–cell adhesive events are mediated by the dimerization of cadherin proteins
presented on apposing cell surfaces. Cadherin-mediated processes play a central role in …

Background E-cadherin plays a pivotal role in tissue morphogenesis by forming clusters that
support intercellular adhesion and transmit tension. What controls E-cadherin mesoscopic …

Cadherins play a key role in the dynamics of cell–cell contact formation and remodeling of
junctions and tissues. Cadherin–cadherin interactions are gated by extracellular Ca2+ …

The cadherin family of Ca2+-dependent cell adhesion proteins are critical for the
morphogenesis and functional organization of tissues in multicellular organisms, but the …

The cadherin extracellular region produces intercellular adhesion clusters through trans-and
cis-intercadherin bonds, and the intracellular region connects these clusters to the …