There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors
of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The …

Liver damage leads to an inflammatory response and to the activation and proliferation of
mesenchymal cell populations within the liver which remodel the extracellular matrix as part …

Fibrosis accumulation is a dynamic process resulting from a wound-healing response to
acute or chronic liver injury of all causes. The cascade starts with hepatocyte necrosis and …

Liver fibrosis and hepatocellular carcinoma (HCC) have been worldwide threats nowadays.
Liver fibrosis is reversible in early stages but will develop precancerosis of HCC in cirrhotic …

Hepatic fibrosis, characterized by excessive accumulation of extracellular matrix (ECM)
proteins leading to liver dysfunction, is a growing cause of mortality worldwide …

Hepatic fibrosis represents the wound‐healing response process of the liver to chronic
injury, independently from aetiology. Advanced liver fibrosis results in cirrhosis that can lead …

This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …